Detectives believe the 43-year-old woman had been sexually assaulted by a group of males.
The suspects include a 12-year-old boy and three 13-year-old boys.
The other males who were held were three aged 15, and individuals aged 16, 18 and 19.
All 10 males, who come from the Anfield, Walton, Everton and Old Swan areas, and the 15-year-old girl have all been released on bail pending further enquiries.
Paramedics had called police after they went to a property in Ullswater Street and reported a woman had been subjected to a sexual offence at 4.20pm on 24 September.
Detective Superintendent Tim Keelan, said: “The victim has been distressed by her ordeal and is being supported by specialist officers.
“This was an appalling attack on a woman in her own home and we would urge anyone who has information, which could help us bring those responsible to justice, to come forward.
“It is possible that some of those who were in the flat on the day may have talked to people, including friends or family, about what happened and if they have we would urge them to contact us.”
Anyone with information should contact the specialist Unity team on 0151 777 1382, or Crimestoppers on 0800 555 111.